The Perlson Laboratory
for Molecular Neurodegeneration
Studying mechanisms of axon and NMJ maintenance
in health and disease
The goal of the Perlson lab is to elucidate the molecular mechanisms of motor neuron degeneration in ALS. In particular, we focus on understanding the interplay between axonal transport and local protein synthesis events, in axons and neuromuscular junction degeneration/regeneration process. We take a fresh approach to this challenge combining advanced microscopy, Tg mice models, human iPSC, and a unique Lab-on-a-Chip that mimics the motor unit. This platform enables the growth of neurons and muscle on a silicon chip and provides a powerful tool for studying new neuromuscular junction biology.
JCS | 2019
This work compares the synaptic mitochondria populations in two types of peripheral neurons and their synaptic compartments: motor neurons and sympathetic neurons.
We identified that, unlike the sympathetic synapses, neuromuscular junctions are rich with mitochondria, and depend on their ATP production in order to function.
Prof. Eran Perlson,
Department of Physiology and Pharmacology.
Sackler Faculty of Medicine.
30 Haim Levanon st.,
Tel Aviv 69978