Science Lab

Key Publications

Axonal TDP-43 condensates drive neuromuscular junction disruption through inhibition of local synthesis of nuclear-encoded mitochondrial proteins

Altman T, Ionescu A, Ibraheem A, Priesmann D, Gradus-Pery T, Farberov L, Gayster A, Shelestovich N, Dafinca R, Shomron N, Rage F, Talbot K, Ward ME, Dori A, Krüger M, and Perlson E..
Nat Commun. 2021 Nov 25;12(1):6914. doi: 10.1038/s41467-021-27221-8

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A CRMP4-dependent retrograde axon-to-soma death signal in amyotrophic lateral sclerosis.

Maimon R, Ankol L, Gradus Pery T, Altman T, Ionescu A, Weissova R, Ostrovsky M, Tank E, Alexandra G, Shelestovich N, Opatowsky Y, Dori A, Barmada S, Balastik M, Perlson E.
EMBO J. 2021 Jun 30:e107586. doi: 10.15252/embj.2020107586

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miR126-5p Downregulation Facilitates Axon Degeneration and NMJ Disruption via a Non-Cell-Autonomous Mechanism in ALS.

Maimon R, Ionescu A, Bonnie A, Sweetat S, Wald-Altman S, Inbar S, Gradus T, Trotti D, Weil M, Behar O, Perlson E.

J Neurosci. 2018 Jun 13;38(24):5478-5494. doi: 10.1523/JNEUROSCI.3037-17.2018. Epub 2018 May 17.PMID: 29773756 

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An in vitro compartmental system underlines the contribution of mitochondrial immobility to the ATP supply in the NMJ.

Altman T, Geller D, Kleeblatt E, Gradus-Perry T, Perlson E.

J Cell Sci. 2019 Dec 2;132(23):jcs234492. doi: 10.1242/jcs.234492.PMID: 31722980

Targeting the Sigma-1 Receptor via Pridopidine Ameliorates Central Features of ALS Pathology in a SOD1G93A Model.

Ionescu A, Gradus T, Altman T, Maimon R, Saraf Avraham N, Geva M, Hayden M, Perlson E.

Cell Death Dis. 2019 Mar 1;10(3):210. doi: 10.1038/s41419-019-1451-2.PMID: 30824685 

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Localization of RNAi Machinery to Axonal Branch Points and Growth Cones Is Facilitated by Mitochondria and Is Disrupted in ALS.

Gershoni-Emek N, Altman T, Ionescu A, Costa CJ, Gradus-Pery T, Willis DE, Perlson E.

Front Mol Neurosci. 2018 Sep 5;11:311. doi: 10.3389/fnmol.2018.00311. eCollection 2018.PMID: 30233312 

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The receptor tyrosine kinase TrkB signals without dimerization at the plasma membrane.

Zahavi EE, Steinberg N, Altman T, Chein M, Joshi Y, Gradus-Pery T, Perlson E.

Sci Signal. 2018 May 8;11(529):eaao4006. doi: 10.1126/scisignal.aao4006.PMID: 29739881

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ALS Along the Axons - Expression of Coding and Noncoding RNA Differs in Axons of ALS models.

Rotem N, Magen I, Ionescu A, Gershoni-Emek N, Altman T, Costa CJ, Gradus T, Pasmanik-Chor M, Willis DE, Ben-Dov IZ, Hornstein E, Perlson E.

Sci Rep. 2017 Mar 16;7:44500. doi: 10.1038/srep44500.PMID: 28300211 

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Proteomic Analysis of Dynein-Interacting Proteins in Amyotrophic Lateral Sclerosis Synaptosomes Reveals Alterations in the RNA-Binding Protein Staufen1.

Gershoni-Emek N, Mazza A, Chein M, Gradus-Pery T, Xiang X, Li KW, Sharan R, Perlson E.

Mol Cell Proteomics. 2016 Feb;15(2):506-22. doi: 10.1074/mcp.M115.049965. Epub 2015 Nov 23.PMID: 26598648 

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A compartmentalized microfluidic neuromuscular co-culture system reveals spatial aspects of GDNF functions.

Zahavi EE, Ionescu A, Gluska S, Gradus T, Ben-Yaakov K, Perlson E.

J Cell Sci. 2015 Mar 15;128(6):1241-52. doi: 10.1242/jcs.167544. Epub 2015 Jan 27. PMID: 25632161 

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Rabies Virus Hijacks and accelerates the p75NTR retrograde axonal transport machinery.

Gluska S, Zahavi EE, Chein M, Gradus T, Bauer A, Finke S, Perlson E.

PLoS Pathog. 2014 Aug 28;10(8):e1004348. doi: 10.1371/journal.ppat.1004348. eCollection 2014 Aug.PMID: 25165859 

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